Eligibility Criteria

Patients will be able to join the trial if they are:

  • Adults (18 years or older)
  • Staphylococcus aureus (meticillin-susceptible or resistant) grown from at least one blood culture
  • Less than 96 hours of active antibiotic therapy for the current infection, not including rifampicin, and excluding any stat doses.
  • Patient or legal representative (LR) provides written informed consent

Patients will not be able to join the trial if:

  • Infection not caused by S. aureus alone in the opinion of the infection specialist (e.g. S. aureus is considered a blood culture contaminant, or polymicrobial culture with another organism likely to be contributing clinically to the current infection)
  • Sensitivity results already available and demonstrate rifampicin resistant S. aureus (defined by British Society for Antimicrobial Chemotherapy in vitro disc susceptibility testing or by Vitek testing)
  • Infection specialist, in consultation with the treating physician, considers rifampicin is contraindicated for any reason
  • Infection specialist, in consultation with the treating physician, considers rifampicin treatment is mandatory for any reason
  • Infection specialist suspects active infection with Mycobacterium tuberculosis
  • Previously been randomised in ARREST for a prior episode of S. aureus bacteraemia

Arrest Trial

MRC Clinical Trials Unit at UCL
Aviation House
90 High Holborn
2nd Floor
London
WC1V 6LJ

Email: mrcctu.arrest@ucl.ac.uk